AOF Recombinant Protein

Animal Origin Free Recombinant Protein

AOF

Leveraging on our strengths in core biotechnology, bioprocess development, developing global partnerships, and effective supply chain management, we continue to add value in Bio-Manufacturing, Stem Cell & Regenerative Medicine & Cell Culture segments by helping customers move toward a 100 % Animal Origin Free (AOF) process.

Our expertise lies in microbial strain development, bioprocess development and optimization, assay development and validation, scale up, and application development.

With more than 40% of our staff dedicated to R&D and scale up efforts, our fully integrated R&D centre  staff consists of accomplished PhDs and researchers from leading institutions worlwide.

OUR VALUE ADD
  • We enabled a leading insulin/analog manufacturer to not only transition from using bovine source trypsin to AOF trypsin in its processes but importantly also reduced the amount of trypsin used in its processes.
  • We added significant value to a global vaccine manufacturer by providing a first in class customised formulation of recombinant trypsin.
  • We are enabling insulin and Mab manufacturers worldwide replace porcine, bovine or human source carboxypeptidase B (CPB) in their processes with recombinant CPB that is comparable to the gold standard.
  • We provide a cost-effective and high quality grade of recombinant trypsin for application in the price sensitive animal vaccine industry.
  • We save critical resources and time for our global partners by collaborating on the development of high value recombinant proteins for use in the stem cell and regenerative medicine industry.

HUMAN ALBUMIN    |   TRYPSIN   |   CELL DISSOCIATION AGENT   |   CARBOXYPEPTIDASE B

RECOMBINANT HUMAN ALBUMIN

Richcore's r-human albumin products are expressed in Pichia Pastoris using an artificially synthesized gene of human albumin as genetic construct.

These products are manufactured in Richcore's GMP certified facility, are 100% Animal Origin Free (AOF) level 3, stable, and free from viral contaminants. Over the past few years, biomanufacturing and regenerative medicine companies have been moving toward use of AOF albumin. Richcore's 100% AOF recombinant human albumin products have been developed to support these companies in eliminating any risk of viral contamination from blood source and overcoming inconsistencies related to supply issues originated from varying availability of blood supply.

Richcore has developed different grades of r-human albumin for the following applications:       

  • Stem cell research, cell culturing and regenerative medicine.
  • Stabiliser in non-therapeutic proteins
  • Stabilizer in vaccines and other biotherapeutics
  • Therapeutics for treating hypoproteinaemia, blood loss trauma, and dry eyes.
  • Key ingredient in cosmeceuticals and nutraceuticals
RECOMBINANT TRYPSIN (Rc Trypsin)

Richcore's Rc Trypsin™ products are expressed in Pichia pastoris using an artificially synthesised gene as genetic construct. The products are manufactured in Richcore’s GMP certified facility, are 100% Animal Origin Free (AOF) level 3, stable, and free from viral contaminants and contaminating proteases such as Carboxypeptidase A and Chymotrypsin.Richcore supplies different grades of Rc Trypsin for application in:

  • Insulin Manufacturing: To convert proinsulin to mature insulin
  • Vaccine Manufacturing: To passage cells and for viral propagation via proteolytic action
  • Stem Cell research and regenerative medicine: To harvest and culture cells and tissues
  • Process aid in food processing
  • Key ingredient in cosmeceutical formulations for exfoliation and wound healing
RECOMBINANT CELL DISSOCIATION RE-AGENT (Rc TrpCell)

Richcore's Rc TrpCell products is a ready-to-use recombinant protein based dissociation reagent. The product is easy to use, and manufactured in Richcore’s GMP certified facility. The product is 100% Animal Origin Free (AOF) level 3, stable, and free from viral contaminants.Richcore supplies different grades of Rc TrpCell for application in:

  • Standard cell culture: To harvest and culture cells and tissues
  • Stem Cell research and regenerative medicine: To harvest and culture cells and tissues
RECOMBINANT CARBOXYPEPTIDASE B (Rc CPB-rat sequence)

Richcore's Rc CPB products are expressed in Pichia pastoris using artificially synthesized genes of rat Carboxypeptidase B and manufactured using a 100% Animal Origin Free (AOF) process.

The products are free of contaminating proteases such as Carboxypeptidase A and Chymotrypsin. The products do not contain any contamination from viruses and other agents.

Richcore supplies Rc CPB for application in:

  • Insulin Manufacturing: To convert proinsulin to mature insulin.
  • Biologics Manufacturing: To cleave unwanted peptide side chains in the purification of recombinant biologics
  • Proteomics: In the cleaving of long peptide chains for mass spectrometry